CoBRA Methods

A comprehensive compilation of methods in constraint-based reconstruction and analysis

Welcome to the home of a comprehensive catalog of constraint-based methods and software packages. This contains detailed information for all methods that have been derived from Flux Balance Analysis, Elementary Flux Mode Analysis, and Extreme Pathway Analysis.

Constraint-based methods

Software packages

This site is accompanied by a comprehensive review on methods in constraint-based modeling:

Lewis NE, Nagarajan H, Palsson BO. Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods. Nature Reviews Microbiology. (2012)

We invite the constraint-based community to contribute to descriptions on new or existing constraint-based methods. For information on acquiring editing permissions for this site, click here.

Website developed by Nathan Lewis and Bretton Neville.

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