CASOP: computational approach for strain optimization aiming at high productivity

General concept

CASOP is a heuristic approach for increasing the specific productivity of strains. The relative contribution of a reaction to product yield and network capacity is estimated by analyzing the spectrum of elementary flux modes. A reaction ranking is delivered suggesting gene knockout and overexpression candidates.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

H├Ądicke and Klamt

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