COBRA without mass balance

General concept

The Von Neumann model is applied to metabolism, without requiring mass balance or stationarity of flux. However, these are essentially recovered at maximum growth. This shows, however that mass balance is met for almost all metabolites, suggesting a correction for FBA.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

Martelli, et al.

Related methods

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