Elementary Modes

General concept

Elementary modes represent the generating vectors of the flux polytope. These pathways can be combined to describe any feasible steady state flux distribution.

Items to consider when implementing

Software packages with this method

Applications of interest

Terzer and Stelling, provided an algorithmic improvement on this approach using bit pattern trees.

Relevant references

Schuster S, Hilgetag C.On elementary flux modes in biochemical reaction systems at steady state. Journal of Biological Systems.
2(2), 165-182 (1994) DOI: 10.1142/S0218339094000131

Terzer M, Stelling J. Large-scale computation of elementary flux modes with bit pattern trees. Bioinformatics. 2008 Oct 1;24(19):2229-35.

Related methods

Extreme currents

Extreme pathways (ExPas)

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