Extreme pathways (ExPas)

General concept

Extreme pathways represent the edges of the flux polytope, and are linearly independent steady state pathways. These pathways can be combined to describe any feasible steady state flux distribution.

Items to consider when implementing

Software packages with this method


Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

Schilling CH, Letscher D, Palsson BO. Theory for the systemic definition of metabolic pathways and their use in interpreting metabolic function from a pathway-oriented perspective. J Theor Biol. 2000 Apr 7;203(3):229-48.

Yeung M, Thiele I, Palsson BO. Estimation of the number of extreme pathways for metabolic networks. BMC Bioinformatics. 2007 Sep 27;8(1):363.

Related methods

Extreme currents

Elementary modes

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