Flux balance impact degree

General concept

This method provides a variation on the concept of impact degree (i.e., the impact of a gene deletion in a metabolic network), that enables one to account for reaction directionality and environmental conditions. This can be done using linear programming or elementary flux modes. This approach also does not require the definition of an objective function.

Items to consider when implementing

Software packages with this method

Applications of interest

Relevant references

Zhao Y, Tamura T, Akutsu T, Vert JP. Flux balance impact degree: a new definition of impact degree to properly treat reversible reactions in metabolic networks. Bioinformatics. 2013 Jul 10.

Related methods

Flux variability analysis
Elementary modes

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