Flux minimization

General concept

The "cost" of enzyme usage in a network is likely minimized by evolution. Moreover, the binary definition of reactions as reversible and irreversible may provide incorrect flux predictions. Thus, by minimizing flux, weighted by equilibrium constants to account for reaction reversibility. To predict flux values, flux is minimized in the metabolic network, subject to a weighted linear combination of individual fluxes, weighted by the thermodynamic equilibrium constants.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

Holzh├╝tter HG. The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks. Eur J Biochem. 2004 Jul;271(14):2905-22.

Related methods

Parsimonious enzyme usage FBA (pFBA)

Unless otherwise stated, the content of this page is licensed under Creative Commons Attribution-ShareAlike 3.0 License