Flux minimization
General concept
The "cost" of enzyme usage in a network is likely minimized by evolution. Moreover, the binary definition of reactions as reversible and irreversible may provide incorrect flux predictions. Thus, by minimizing flux, weighted by equilibrium constants to account for reaction reversibility. To predict flux values, flux is minimized in the metabolic network, subject to a weighted linear combination of individual fluxes, weighted by the thermodynamic equilibrium constants.
Items to consider when implementing
Software packages with this method
Applications of interest
Description of study and link to study:
What was learned with this method:
Relevant references
Holzhütter HG. The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks. Eur J Biochem. 2004 Jul;271(14):2905-22.
Related methods
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