Noninferior set estimation (NISE) for multiobjective balancing

General concept

FBA computes solutions to single objectives, while in reality, cells might be balancing several cellular objectives. Thus, a multiple objective approach is suggested. The NISE generates an approximation of the Pareto curve showing the balance between multiple competing objectives. This is done without having to iterate single objective optimizations. This method also allows the investigation of flux distributions for each Pareto optimal solution.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

Oh, et al.

Related methods

Multi-product trade-off analysis

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