General concept

Desired products can be obtained not only through the deletion of extant metabolic reactions, but also through the up- and down-regulation of other reactions. These modifications can be identified in silico. This method extends OptKnock by providing additional variables and non-linearities. These additions allow for the prediction of reactions that can be up- or down-regulated to aid in strain design.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

Pharkya and Maranas

Related methods

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