Quantitative assignment of reaction directionality in constraint-based models of metabolism

General concept

Thermodynamic constraints for a model are calculated using group contribution estimates and reaction equilibrium constants, while accounting for the in vivo pH, osmolarity, and temperature.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

Fleming, et al.

Related methods

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