Strain design with Simulated Annealing (SA)

General concept

The space of possible gene or reaction deletion strain designs can be searched using simulated annealing. This method does not require the user to specify the number of reaction deletions a priori. In the SA approach, the space of possible reaction deletions is searched in a stochasitic manner. Less optimal solutions are accepted with a probability to avoid local optima. This approach can be applied to gene or reaction deletions.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

Rocha, et al.

Related methods