Sampling-based loop removal

General concept

The loop law states that the net flux around closed biochemical loops must equal zero because of a lack of a net thermodynamic driving force. In this method the necessary linear equality constraints for thermodynamic feasibility are determined, and then the bounds on those are tightened to enclose the solution space. MCMC sampling is then used to sample the convex space. All solution samples are tested, and those violating the loop law are removed.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

Price, et al.

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