Transcriptional-controlled FBA (tFBA)

General concept

This approach uses regulatory up/down constraints based on differential gene expression data in FBA optimization. An MILP is formulated that minimizes the number of violated up/down constraints between models under the two given substrates.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

van Berlo, et al.

Related methods

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