Thermodynamically-weighted elementary modes

General concept

Thermodynamics are used to weight elementary modes as follows. Genetic algorithms are used to evolve an optimal product or biomass yield based on a fitness criterion. Elementary modes are then enumerated and a flux distribution is made by combining elementary modes, with weights based on the change in Gibbs free energy for each pathway. The strain fitness is then evaluated and used to enrich the population in the genetic algorithm.

Items to consider when implementing

Software packages with this method

Applications of interest

Description of study and link to study:

What was learned with this method:

Relevant references

Boghigian, et al.

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